MAPK10

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase 10

PDB rendering based on 1jnk.

Available structures: 1jnk, 1pmn, 1pmq, 1pmu, 1pmv, 1ukh, 1uki, 2b1p, 2exc, 2g01, 2gmx, 2h96, 2no3, 2o0u, 2o2u, 2ok1

Identifiers

Symbol(s)

MAPK10; FLJ12099; FLJ33785; JNK3; JNK3A; MGC50974; PRKM10; p493F12; p54bSAPK

External IDs

OMIM: 602897 MGI: 1346863 HomoloGene: 56439

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • JUN kinase activity • MAP kinase activity • MAP kinase kinase activity • protein binding • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • signal transduction • JNK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002753 (mRNA)
NP_002744 (protein)

NM_176970 (mRNA)
NP_795944 (protein)

Location

Chr 4: 87.16 - 87.51 Mb

Chr 5: 103.15 - 103.45 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase 10, also known as MAPK10, is a human gene.^[1]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAPK10 mitogen-activated protein kinase 10.

[edit] Further reading

Freedman BD, Liu QH, Del Corno M, Collman RG (2004). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages.". Immunol. Res. 27 (2-3): 261–76. PMID 12857973.
Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
Pulverer BJ, Kyriakis JM, Avruch J, et al. (1991). "Phosphorylation of c-jun mediated by MAP kinases.". Nature 353 (6345): 670–4. doi:10.1038/353670a0. PMID 1922387.
Mohit AA, Martin JH, Miller CA (1995). "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system.". Neuron 14 (1): 67–78. PMID 7826642.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Gupta S, Barrett T, Whitmarsh AJ, et al. (1996). "Selective interaction of JNK protein kinase isoforms with transcription factors.". EMBO J. 15 (11): 2760–70. PMID 8654373.
Jabado N, Pallier A, Jauliac S, et al. (1997). "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes.". Eur. J. Immunol. 27 (2): 397–404. PMID 9045910.
Yang DD, Kuan CY, Whitmarsh AJ, et al. (1997). "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.". Nature 389 (6653): 865–70. doi:10.1038/39899. PMID 9349820.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Hu MC, Qiu WR, Wang YP (1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases.". Oncogene 15 (19): 2277–87. doi:10.1038/sj.onc.1201401. PMID 9393873.
Lannuzel A, Barnier JV, Hery C, et al. (1998). "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons.". Ann. Neurol. 42 (6): 847–56. doi:10.1002/ana.410420605. PMID 9403476.
Xie X, Gu Y, Fox T, et al. (1998). "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.". Structure 6 (8): 983–91. PMID 9739089.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Koyano S, Ito M, Takamatsu N, et al. (1999). "A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1.". FEBS Lett. 457 (3): 385–8. PMID 10471813.
Ito M, Yoshioka K, Akechi M, et al. (1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.". Mol. Cell. Biol. 19 (11): 7539–48. PMID 10523642.
Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.". Mol. Cell. Biol. 20 (3): 1030–43. PMID 10629060.
Lisnock J, Griffin P, Calaycay J, et al. (2000). "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.". Biochemistry 39 (11): 3141–8. PMID 10715136.
McDonald PH, Chow CW, Miller WE, et al. (2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.". Science 290 (5496): 1574–7. PMID 11090355.
Pouysségur J (2000). "Signal transduction. An arresting start for MAPK.". Science 290 (5496): 1515–8. PMID 11185509.
Habelhah H, Shah K, Huang L, et al. (2001). "ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.". Nat. Cell Biol. 3 (3): 325–30. doi:10.1038/35060131. PMID 11231586.