MAP6

From Wikipedia, the free encyclopedia


Microtubule-associated protein 6
Identifiers
Symbol(s) MAP6; FLJ41346; KIAA1878; MTAP6; N-STOP; STOP
External IDs OMIM: 601783 MGI: 1201690 HomoloGene: 7850
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4135 17760
Ensembl ENSG00000171533 ENSMUSG00000055407
Refseq NM_033063 (mRNA)
NP_149052 (protein)		 NM_001043355 (mRNA)
NP_001036820 (protein)
Location Chr 11: 74.98 - 75.06 Mb Chr 7: 99.14 - 99.21 Mb
Pubmed search [1] [2]

Microtubule-associated protein 6, also known as MAP6, is a human gene.[1]

This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: MAP6 microtubule-associated protein 6.

[edit] Further reading

  • Bosc C, Cronk JD, Pirollet F, et al. (1996). "Cloning, expression, and properties of the microtubule-stabilizing protein STOP.". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 2125–30. PMID 8700896. 
  • Denarier E, Aguezzoul M, Jolly C, et al. (1998). "Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6).". Biochem. Biophys. Res. Commun. 243 (3): 791–6. doi:10.1006/bbrc.1998.8179. PMID 9501006. 
  • Jolly C, Denarier E, Mongelard F, et al. (1999). "Assignment of the STOP gene (MAP6) to human chromosome bands 6p12-->p11 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 86 (1): 25. PMID 10516426. 
  • Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055. 
  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906. 
  • Andrieux A, Salin PA, Vernet M, et al. (2002). "The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.". Genes Dev. 16 (18): 2350–64. doi:10.1101/gad.223302. PMID 12231625. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bosc C, Andrieux A, Job D (2003). "STOP proteins.". Biochemistry 42 (42): 12125–32. doi:10.1021/bi0352163. PMID 14567673. 
  • Letournel F, Bocquet A, Dubas F, et al. (2004). "Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis.". J. Neuropathol. Exp. Neurol. 62 (12): 1211–9. PMID 14692697. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
 This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.