MAP4K4

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase kinase 4

Identifiers

MAP4K4; NIK; FLH21957; FLJ10410; FLJ20373; FLJ90111; HGK; KIAA0687

External IDs

OMIM: 604666 MGI: 1349394 HomoloGene: 7442

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • small GTPase regulator activity • ATP binding • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• protein amino acid phosphorylation • response to stress • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004834 (mRNA)
NP_004825 (protein)

NM_008696 (mRNA)
NP_032722 (protein)

Location

Chr 2: 101.68 - 101.88 Mb

Chr 1: 39.85 - 39.97 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase kinase 4, also known as MAP4K4, is a human gene.^[1]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4.

[edit] Further reading

Su YC, Han J, Xu S, et al. (1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain.". EMBO J. 16 (6): 1279–90. doi:10.1093/emboj/16.6.1279. PMID 9135144.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Yao Z, Zhou G, Wang XS, et al. (1999). "A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway.". J. Biol. Chem. 274 (4): 2118–25. PMID 9890973.
Becker E, Huynh-Do U, Holland S, et al. (2000). "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation.". Mol. Cell. Biol. 20 (5): 1537–45. PMID 10669731.
Zhao ZS, Manser E, Lim L (2000). "Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation.". Mol. Cell. Biol. 20 (11): 3906–17. PMID 10805734.
Hofer-Warbinek R, Schmid JA, Stehlik C, et al. (2000). "Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.". J. Biol. Chem. 275 (29): 22064–8. doi:10.1074/jbc.M910346199. PMID 10807933.
Chaudhary PM, Eby MT, Jasmin A, et al. (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs.". Oncogene 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. PMID 11002417.
Yan W, Nehrke K, Choi J, Barber DL (2001). "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor.". J. Biol. Chem. 276 (33): 31349–56. doi:10.1074/jbc.M102679200. PMID 11369779.
Poinat P, De Arcangelis A, Sookhareea S, et al. (2002). "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.". Curr. Biol. 12 (8): 622–31. PMID 11967148.
Fong A, Zhang M, Neely J, Sun SC (2002). "S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100.". J. Biol. Chem. 277 (43): 40697–702. doi:10.1074/jbc.M205330200. PMID 12185077.
Luan Z, Zhang Y, Liu A, et al. (2002). "A novel GTP-binding protein hGBP3 interacts with NIK/HGK.". FEBS Lett. 530 (1-3): 233–8. PMID 12387898.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wright JH, Wang X, Manning G, et al. (2003). "The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.". Mol. Cell. Biol. 23 (6): 2068–82. PMID 12612079.
Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Machida N, Umikawa M, Takei K, et al. (2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.". J. Biol. Chem. 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Collins CS, Hong J, Sapinoso L, et al. (2006). "A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.". Proc. Natl. Acad. Sci. U.S.A. 103 (10): 3775–80. doi:10.1073/pnas.0600040103. PMID 16537454.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.