MAP4K2

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase kinase 2

Identifiers

MAP4K2; GCK; BL44; RAB8IP

External IDs

OMIM: 603166 MGI: 1346883 HomoloGene: 3370

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • small GTPase regulator activity • protein binding • ATP binding • transferase activity
Cellular Component:	• Golgi membrane • soluble fraction
Biological Process:	• protein amino acid phosphorylation • vesicle targeting • response to stress • immune response • protein kinase cascade • JNK cascade • hemocyte development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004579 (mRNA)
NP_004570 (protein)

NM_009006 (mRNA)
NP_033032 (protein)

Location

Chr 11: 64.31 - 64.33 Mb

Chr 19: 6.34 - 6.35 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase kinase 2, also known as MAP4K2, is a human gene.^[1]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2.

[edit] Further reading

Vionnet N, Stoffel M, Takeda J, et al. (1992). "Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.". Nature 356 (6371): 721-2. doi:10.1038/356721a0. PMID 1570017.
Matsutani A, Janssen R, Donis-Keller H, Permutt MA (1992). "A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p.". Genomics 12 (2): 319-25. PMID 1740341.
Pombo CM, Kehrl JH, Sánchez I, et al. (1995). "Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase.". Nature 377 (6551): 750-4. doi:10.1038/377750a0. PMID 7477268.
Katz P, Whalen G, Kehrl JH (1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center.". J. Biol. Chem. 269 (24): 16802-9. PMID 7515885.
Ren M, Zeng J, De Lemos-Chiarandini C, et al. (1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 5151-5. PMID 8643544.
Guru SC, Agarwal SK, Manickam P, et al. (1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.". Genome Res. 7 (7): 725-35. PMID 9253601.
Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38.". J. Biol. Chem. 273 (35): 22681-92. PMID 9712898.
Chadee DN, Yuasa T, Kyriakis JM (2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.". Mol. Cell. Biol. 22 (3): 737-49. PMID 11784851.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537-47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.