MAP3K9

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase 9

Identifiers

MAP3K9; MLK1; PRKE1

External IDs

OMIM: 600136 MGI: 2449952 HomoloGene: 76377

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • JUN kinase kinase kinase activity • MAP kinase kinase activity • protein-tyrosine kinase activity • ATP binding • transferase activity • protein homodimerization activity
Cellular Component:	• cellular_component
Biological Process:	• activation of JNK activity • protein amino acid autophosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_033141 (mRNA)
NP_149132 (protein)

XM_974511 (mRNA)
XP_979605 (protein)

Location

Chr 14: 70.26 - 70.35 Mb

n/a

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase 9, also known as MAP3K9, is a human gene.^[1]

[edit] References

^ Entrez Gene: MAP3K9 mitogen-activated protein kinase kinase kinase 9.

[edit] Further reading

Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.". J. Biol. Chem. 269 (21): 15092-100. PMID 8195146.
Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.". Eur. J. Biochem. 213 (2): 701-10. PMID 8477742.
Dorow DS, Devereux L, Tu GF, et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.". Eur. J. Biochem. 234 (2): 492-500. PMID 8536694.
Xu Z, Maroney AC, Dobrzanski P, et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.". Mol. Cell. Biol. 21 (14): 4713-24. doi:10.1128/MCB.21.14.4713-4724.2001. PMID 11416147.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.". J. Biol. Chem. 278 (48): 47922-7. doi:10.1074/jbc.M307357200. PMID 14504284.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Durkin JT, Holskin BP, Kopec KK, et al. (2005). "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.". Biochemistry 43 (51): 16348-55. doi:10.1021/bi049866y. PMID 15610029.