MAP3K7

From Wikipedia, the free encyclopedia

Main article: MAP kinase kinase kinase

Mitogen-activated protein kinase kinase kinase 7

PDB rendering based on 2eva.

Available structures: 2eva

Identifiers

Symbol(s)

MAP3K7; TAK1; TGF1a

External IDs

OMIM: 602614 MGI: 1346877 HomoloGene: 37743

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Biological Process:	• MAPKKK cascade • angiogenesis • neural tube formation • positive regulation of T cell cytokine production • protein amino acid phosphorylation • transforming growth factor beta receptor signaling pathway • activation of NF-kappaB-inducing kinase • I-kappaB phosphorylation • negative regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of JNK cascade • T cell receptor signaling pathway • positive regulation of T cell activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003188 (mRNA)
NP_003179 (protein)

NM_172688 (mRNA)
NP_766276 (protein)

Location

Chr 6: 91.28 - 91.35 Mb

Chr 4: 32.29 - 32.35 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase 7, also known as MAP3K7, is a human gene.

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

[edit] References

^ Entrez Gene: MAP3K7 mitogen-activated protein kinase kinase kinase 7.

[edit] Further reading

DuBridge RB, Tang P, Hsia HC, et al. (1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.". Mol. Cell. Biol. 7 (1): 379–87. PMID 3031469.
Hirose T, Fujimoto W, Tamaai T, et al. (1995). "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.". Mol. Endocrinol. 8 (12): 1667–80. PMID 7708055.
Yamaguchi K, Shirakabe K, Shibuya H, et al. (1996). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.". Science 270 (5244): 2008–11. PMID 8533096.
Shibuya H, Yamaguchi K, Shirakabe K, et al. (1996). "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.". Science 272 (5265): 1179–82. PMID 8638164.
Wang W, Zhou G, Hu MC, et al. (1997). "Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction.". J. Biol. Chem. 272 (36): 22771–5. PMID 9278437.
Liu X, Sun Y, Constantinescu SN, et al. (1997). "Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 94 (20): 10669–74. PMID 9380693.
Kondo M, Osada H, Uchida K, et al. (1998). "Molecular cloning of human TAK1 and its mutational analysis in human lung cancer.". Int. J. Cancer 75 (4): 559–63. PMID 9466656.
Sakurai H, Shigemori N, Hasegawa K, Sugita T (1998). "TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.". Biochem. Biophys. Res. Commun. 243 (2): 545–9. doi:10.1006/bbrc.1998.8124. PMID 9480845.
Yan ZH, Karam WG, Staudinger JL, et al. (1998). "Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4.". J. Biol. Chem. 273 (18): 10948–57. PMID 9556573.
Lee FS, Peters RT, Dang LC, Maniatis T (1998). "MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. PMID 9689078.
Yamaguchi K, Nagai S, Ninomiya-Tsuji J, et al. (1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.". EMBO J. 18 (1): 179–87. doi:10.1093/emboj/18.1.179. PMID 9878061.
Lallena MJ, Diaz-Meco MT, Bren G, et al. (1999). "Activation of IkappaB kinase beta by protein kinase C isoforms.". Mol. Cell. Biol. 19 (3): 2180–8. PMID 10022904.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, et al. (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.". Nature 398 (6724): 252–6. doi:10.1038/18465. PMID 10094049.
Sakurai H, Miyoshi H, Toriumi W, Sugita T (1999). "Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation.". J. Biol. Chem. 274 (15): 10641–8. PMID 10187861.
Delhase M, Hayakawa M, Chen Y, Karin M (1999). "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.". Science 284 (5412): 309–13. PMID 10195894.
Zhou G, Lee SC, Yao Z, Tan TH (1999). "Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade.". J. Biol. Chem. 274 (19): 13133–8. PMID 10224067.
Kimura N, Matsuo R, Shibuya H, et al. (2000). "BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6.". J. Biol. Chem. 275 (23): 17647–52. doi:10.1074/jbc.M908622199. PMID 10748100.
Yamamoto Y, Yin MJ, Gaynor RB (2000). "IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.". Mol. Cell. Biol. 20 (10): 3655–66. PMID 10779355.
Hofer-Warbinek R, Schmid JA, Stehlik C, et al. (2000). "Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.". J. Biol. Chem. 275 (29): 22064–8. doi:10.1074/jbc.M910346199. PMID 10807933.
Sakurai H, Miyoshi H, Mizukami J, Sugita T (2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.". FEBS Lett. 474 (2-3): 141–5. PMID 10838074.