MAP3K7IP3

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Mitogen-activated protein kinase kinase kinase 7 interacting protein 3
Identifiers
Symbol(s) MAP3K7IP3; NAP1; MGC45404; TAB3
External IDs OMIM: 300480 MGI: 1913974 HomoloGene: 17673
Orthologs
Human Mouse
Entrez 257397 66724
Ensembl ENSG00000157625 ENSMUSG00000035476
Uniprot Q8N5C8 Q571K4
Refseq NM_152787 (mRNA)
NP_690000 (protein)		 NM_025729 (mRNA)
NP_080005 (protein)
Location Chr X: 30.76 - 30.8 Mb Chr X: 81.83 - 81.89 Mb
Pubmed search [1] [2]

Mitogen-activated protein kinase kinase kinase 7 interacting protein 3, also known as MAP3K7IP3, is a human gene.[1]

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3.

[edit] Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ishitani T, Takaesu G, Ninomiya-Tsuji J, et al. (2004). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMID 14633987. 
  • Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1.". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMID 14670075. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  • Jin G, Klika A, Callahan M, et al. (2004). "Identification of a human NF-kappaB-activating protein, TAB3.". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2028–33. doi:10.1073/pnas.0307314101. PMID 14766965. 
  • Kanayama A, Seth RB, Sun L, et al. (2004). "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.". Mol. Cell 15 (4): 535–48. doi:10.1016/j.molcel.2004.08.008. PMID 15327770. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Besse A, Lamothe B, Campos AD, et al. (2007). "TAK1-dependent signaling requires functional interaction with TAB2/TAB3.". J. Biol. Chem. 282 (6): 3918–28. doi:10.1074/jbc.M608867200. PMID 17158449. 
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