MAP3K7IP2

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase 7 interacting protein 2

PDB rendering based on 2dae.

Available structures: 2dae

Identifiers

Symbol(s)

MAP3K7IP2; FLJ21885; KIAA0733; TAB2

External IDs

OMIM: 605101 MGI: 1915902 HomoloGene: 9019

Gene ontology
Molecular Function:	• signal transducer activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular
Biological Process:	• positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015093 (mRNA)
NP_055908 (protein)

NM_138667 (mRNA)
NP_619608 (protein)

Location

Chr 6: 149.68 - 149.77 Mb

Chr 10: 7.6 - 7.62 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase 7 interacting protein 2, also known as MAP3K7IP2, is a human gene.^[1]

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Shibuya H, Yamaguchi K, Shirakabe K, et al. (1996). "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.". Science 272 (5265): 1179–82. PMID 8638164.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Takaesu G, Kishida S, Hiyama A, et al. (2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.". Mol. Cell 5 (4): 649–58. PMID 10882101.
Takaesu G, Ninomiya-Tsuji J, Kishida S, et al. (2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.". Mol. Cell. Biol. 21 (7): 2475–84. doi:10.1128/MCB.21.7.2475-2484.2001. PMID 11259596.
Qian Y, Commane M, Ninomiya-Tsuji J, et al. (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.". J. Biol. Chem. 276 (45): 41661–7. doi:10.1074/jbc.M102262200. PMID 11518704.
Mizukami J, Takaesu G, Akatsuka H, et al. (2002). "Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.". Mol. Cell. Biol. 22 (4): 992–1000. PMID 11809792.
Sanna MG, da Silva Correia J, Luo Y, et al. (2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.". J. Biol. Chem. 277 (34): 30454–62. doi:10.1074/jbc.M203312200. PMID 12048196.
Baek SH, Ohgi KA, Rose DW, et al. (2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.". Cell 110 (1): 55–67. PMID 12150997.
Jiang Z, Ninomiya-Tsuji J, Qian Y, et al. (2002). "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.". Mol. Cell. Biol. 22 (20): 7158–67. PMID 12242293.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jiang Z, Zamanian-Daryoush M, Nie H, et al. (2003). "Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .". J. Biol. Chem. 278 (19): 16713–9. doi:10.1074/jbc.M300562200. PMID 12609980.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ishitani T, Takaesu G, Ninomiya-Tsuji J, et al. (2004). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMID 14633987.
Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1.". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMID 14670075.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Owerbach D, Piña L, Gabbay KH (2004). "A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes.". Diabetes 53 (7): 1890–3. PMID 15220215.
Kanayama A, Seth RB, Sun L, et al. (2004). "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.". Mol. Cell 15 (4): 535–48. doi:10.1016/j.molcel.2004.08.008. PMID 15327770.