MAP3K7IP1

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Mitogen-activated protein kinase kinase kinase 7 interacting protein 1
PDB rendering based on 2j4o.
Available structures: 2j4o
Identifiers
Symbol(s) MAP3K7IP1; MGC57664; TAB1
External IDs OMIM: 602615 MGI: 1913763 HomoloGene: 4461
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10454 66513
Ensembl ENSG00000100324 ENSMUSG00000022414
Uniprot Q15750 Q1RMY2
Refseq NM_006116 (mRNA)
NP_006107 (protein)		 NM_025609 (mRNA)
NP_079885 (protein)
Location Chr 22: 38.13 - 38.16 Mb Chr 15: 79.96 - 79.99 Mb
Pubmed search [1] [2]

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, also known as MAP3K7IP1, is a human gene.[1]

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1.

[edit] Further reading

  • Shibuya H, Yamaguchi K, Shirakabe K, et al. (1996). "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.". Science 272 (5265): 1179-82. PMID 8638164. 
  • Kurozumi K, Nishita M, Yamaguchi K, et al. (1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling.". Genes Cells 3 (4): 257-64. PMID 9663660. 
  • Yamaguchi K, Nagai S, Ninomiya-Tsuji J, et al. (1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.". EMBO J. 18 (1): 179-87. doi:10.1093/emboj/18.1.179. PMID 9878061. 
  • Ninomiya-Tsuji J, Kishimoto K, Hiyama A, et al. (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.". Nature 398 (6724): 252-6. doi:10.1038/18465. PMID 10094049. 
  • Sakurai H, Miyoshi H, Toriumi W, Sugita T (1999). "Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation.". J. Biol. Chem. 274 (15): 10641-8. PMID 10187861. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208. 
  • Kishimoto K, Matsumoto K, Ninomiya-Tsuji J (2000). "TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.". J. Biol. Chem. 275 (10): 7359-64. PMID 10702308. 
  • Sakurai H, Miyoshi H, Mizukami J, Sugita T (2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.". FEBS Lett. 474 (2-3): 141-5. PMID 10838074. 
  • Ono K, Ohtomo T, Sato S, et al. (2001). "An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.". J. Biol. Chem. 276 (26): 24396-400. doi:10.1074/jbc.M102631200. PMID 11323434. 
  • Qian Y, Commane M, Ninomiya-Tsuji J, et al. (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.". J. Biol. Chem. 276 (45): 41661-7. doi:10.1074/jbc.M102262200. PMID 11518704. 
  • Yanagisawa M, Nakashima K, Takeda K, et al. (2002). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7.". Genes Cells 6 (12): 1091-9. PMID 11737269. 
  • Ge B, Gram H, Di Padova F, et al. (2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.". Science 295 (5558): 1291-4. doi:10.1126/science.1067289. PMID 11847341. 
  • Sakurai H, Nishi A, Sato N, et al. (2002). "TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.". Biochem. Biophys. Res. Commun. 297 (5): 1277-81. PMID 12372426. 
  • Ge B, Xiong X, Jing Q, et al. (2003). "TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1.". J. Biol. Chem. 278 (4): 2286-93. doi:10.1074/jbc.M210918200. PMID 12429732. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ishitani T, Kishida S, Hyodo-Miura J, et al. (2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.". Mol. Cell. Biol. 23 (1): 131-9. PMID 12482967. 
  • Suzawa M, Takada I, Yanagisawa J, et al. (2003). "Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade.". Nat. Cell Biol. 5 (3): 224-30. doi:10.1038/ncb942. PMID 12598905. 
  • Tanno M, Bassi R, Gorog DA, et al. (2003). "Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.". Circ. Res. 93 (3): 254-61. doi:10.1161/01.RES.0000083490.43943.85. PMID 12829618. 
  • Channavajhala PL, Wu L, Cuozzo JW, et al. (2004). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling.". J. Biol. Chem. 278 (47): 47089-97. doi:10.1074/jbc.M306002200. PMID 12975377. 
  • Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1.". Biochem. J. 378 (Pt 1): 27-34. doi:10.1042/BJ20031794. PMID 14670075. 
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