MAP3K1

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase 1

Identifiers

MAP3K1; MAPKKK1; MEKK; MEKK1

External IDs

OMIM: 600982 MGI: 1346872 HomoloGene: 8056

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein binding • ATP binding • zinc ion binding • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• protein amino acid phosphorylation • transforming growth factor beta receptor signaling pathway • apoptotic mitochondrial changes • regulation of cell migration • positive regulation of actin filament polymerization • wound healing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_001128827 (mRNA)
XP_001128827 (protein)

NM_011945 (mRNA)
NP_036075 (protein)

Location

Chr 5: 56.15 - 56.23 Mb

n/a

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase 1, also known as MAP3K1, is a human gene.^[1]

MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1.

[edit] Further reading

Vinik BS, Kay ES, Fiedorek FT (1996). "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5.". Mamm. Genome 6 (11): 782–3. PMID 8597633.
Lee FS, Hagler J, Chen ZJ, Maniatis T (1997). "Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway.". Cell 88 (2): 213–22. PMID 9008162.
Siow YL, Kalmar GB, Sanghera JS, et al. (1997). "Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C.". J. Biol. Chem. 272 (12): 7586–94. PMID 9065412.
Su YC, Han J, Xu S, et al. (1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain.". EMBO J. 16 (6): 1279–90. doi:10.1093/emboj/16.6.1279. PMID 9135144.
Wu Z, Wu J, Jacinto E, Karin M (1997). "Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.". Mol. Cell. Biol. 17 (12): 7407–16. PMID 9372971.
Xu S, Cobb MH (1998). "MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases.". J. Biol. Chem. 272 (51): 32056–60. PMID 9405400.
Fanger GR, Widmann C, Porter AC, et al. (1998). "14-3-3 proteins interact with specific MEK kinases.". J. Biol. Chem. 273 (6): 3476–83. PMID 9452471.
Hirai S, Noda K, Moriguchi T, et al. (1998). "Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2.". J. Biol. Chem. 273 (13): 7406–12. PMID 9516438.
Saltzman A, Searfoss G, Marcireau C, et al. (1998). "hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity.". FEBS Lett. 425 (3): 431–5. PMID 9563508.
Guan Z, Buckman SY, Pentland AP, et al. (1998). "Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway.". J. Biol. Chem. 273 (21): 12901–8. PMID 9582321.
Lee FS, Peters RT, Dang LC, Maniatis T (1998). "MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. PMID 9689078.
Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38.". J. Biol. Chem. 273 (35): 22681–92. PMID 9712898.
Pomérance M, Multon MC, Parker F, et al. (1998). "Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor.". J. Biol. Chem. 273 (38): 24301–4. PMID 9733714.
Xia Y, Wu Z, Su B, et al. (1998). "JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.". Genes Dev. 12 (21): 3369–81. PMID 9808624.
Nemoto S, DiDonato JA, Lin A (1998). "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.". Mol. Cell. Biol. 18 (12): 7336–43. PMID 9819420.
Yujiri T, Sather S, Fanger GR, Johnson GL (1998). "Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.". Science 282 (5395): 1911–4. PMID 9836645.
Baud V, Liu ZG, Bennett B, et al. (1999). "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.". Genes Dev. 13 (10): 1297–308. PMID 10346818.
Kopp E, Medzhitov R, Carothers J, et al. (1999). "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.". Genes Dev. 13 (16): 2059–71. PMID 10465784.
Ito M, Yoshioka K, Akechi M, et al. (1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.". Mol. Cell. Biol. 19 (11): 7539–48. PMID 10523642.
Minamino T, Yujiri T, Papst PJ, et al. (2000). "MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15127–32. PMID 10611349.