MAP3K13

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase 13

Identifiers

MAP3K13; LZK; MGC133196

External IDs

OMIM: 604915 MGI: 2444243 HomoloGene: 37958

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein-tyrosine kinase activity • ATP binding • transferase activity • protein kinase binding • protein homodimerization activity
Cellular Component:	• membrane fraction • IkappaB kinase complex • membrane
Biological Process:	• activation of MAPKK activity • JNK cascade • protein amino acid autophosphorylation • activation of NF-kappaB transcription factor

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004721 (mRNA)
NP_004712 (protein)

XM_484537 (mRNA)
XP_484537 (protein)

Location

Chr 3: 186.56 - 186.68 Mb

Chr 16: 21.84 - 21.84 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase 13, also known as MAP3K13, is a human gene.^[1]

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Masaki M, Ikeda A, Shiraki E, et al. (2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.". Eur. J. Biochem. 270 (1): 76-83. PMID 12492477.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ikeda A, Sakuma H, Masaki M, et al. (2002). "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene.". J. Biochem. Mol. Biol. Biophys. 6 (2): 113-7. doi:10.1080/10258140290027243. PMID 12186766.
Ikeda A, Hasegawa K, Masaki M, et al. (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway.". J. Biochem. 130 (6): 773-81. PMID 11726277.
Ikeda A, Masaki M, Kozutsumi Y, et al. (2001). "Identification and characterization of functional domains in a mixed lineage kinase LZK.". FEBS Lett. 488 (3): 190-5. PMID 11163770.
Sakuma H, Ikeda A, Oka S, et al. (1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain.". J. Biol. Chem. 272 (45): 28622-9. PMID 9353328.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821-30. PMID 8274451.