MAP3K11

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase kinase kinase 11

Identifiers

MAP3K11; MGC17114; MLK-3; MLK3; PTK1; SPRK

External IDs

OMIM: 600050 MGI: 1346880 HomoloGene: 37618

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • JUN kinase kinase kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity • protein homodimerization activity
Cellular Component:	• centrosome • microtubule
Biological Process:	• G1 phase of mitotic cell cycle • microtubule-based process • activation of JNK activity • cell proliferation • regulation of JNK cascade • protein amino acid autophosphorylation • protein oligomerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002419 (mRNA)
NP_002410 (protein)

XM_979737 (mRNA)
XP_984831 (protein)

Location

Chr 11: 65.12 - 65.14 Mb

n/a

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase kinase 11, also known as MAP3K11, is a human gene.

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.^[1]

[edit] References

^ Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11.

[edit] Further reading

van de Bovenkamp M, Nottet HS, Pereira CF (2003). "Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia.". Eur. J. Clin. Invest. 32 (8): 619–27. PMID 12190962.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Ing YL, Leung IW, Heng HH, et al. (1994). "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain.". Oncogene 9 (6): 1745–50. PMID 8183572.
Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.". J. Biol. Chem. 269 (21): 15092–100. PMID 8195146.
Smith CM, Ma NS, Nowak NJ, et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13.". Genome Res. 7 (8): 835–42. PMID 9267807.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMID 9427749.
Tanaka S, Hanafusa H (1998). "Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases.". J. Biol. Chem. 273 (3): 1281–4. PMID 9430657.
Leung IW, Lassam N (1999). "Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3.". J. Biol. Chem. 273 (49): 32408–15. PMID 9829970.
Merritt SE, Mata M, Nihalani D, et al. (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate.". J. Biol. Chem. 274 (15): 10195–202. PMID 10187804.
Yasuda J, Whitmarsh AJ, Cavanagh J, et al. (2000). "The JIP group of mitogen-activated protein kinase scaffold proteins.". Mol. Cell. Biol. 19 (10): 7245–54. PMID 10490659.
Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.". Mol. Cell. Biol. 20 (3): 1030–43. PMID 10629060.
Hehner SP, Hofmann TG, Ushmorov A, et al. (2000). "Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.". Mol. Cell. Biol. 20 (7): 2556–68. PMID 10713178.
Böck BC, Vacratsis PO, Qamirani E, Gallo KA (2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation.". J. Biol. Chem. 275 (19): 14231–41. PMID 10799501.
Leung IW, Lassam N (2001). "The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation.". J. Biol. Chem. 276 (3): 1961–7. doi:10.1074/jbc.M004092200. PMID 11053428.
Svensson AC, Raudsepp T, Larsson C, et al. (2001). "Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9.". Cytogenet. Cell Genet. 92 (1-2): 89–96. PMID 11306803.
Zhang H, Gallo KA (2002). "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.". J. Biol. Chem. 276 (49): 45598–603. doi:10.1074/jbc.M107176200. PMID 11590155.
Lambert JM, Karnoub AE, Graves LM, et al. (2002). "Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation.". J. Biol. Chem. 277 (7): 4770–7. doi:10.1074/jbc.M109379200. PMID 11713255.
Chadee DN, Yuasa T, Kyriakis JM (2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.". Mol. Cell. Biol. 22 (3): 737–49. PMID 11784851.
Vacratsis PO, Phinney BS, Gage DA, Gallo KA (2002). "Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping.". Biochemistry 41 (17): 5613–24. PMID 11969422.