Mannose-1-phosphate guanylyltransferase

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In enzymology, a mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) is an enzyme that catalyzes the chemical reaction

GTP + alpha-D-mannose 1-phosphate $\rightleftharpoons$ diphosphate + GDP-mannose

Thus, the two substrates of this enzyme are GTP and alpha-D-mannose 1-phosphate, whereas its two products are diphosphate and GDP-mannose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-mannose-1-phosphate guanylyltransferase. Other names in common use include GTP-mannose-1-phosphate guanylyltransferase, PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose, pyrophosphorylase), GDP-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, guanosine diphosphomannose pyrophosphorylase, guanosine triphosphate-mannose 1-phosphate guanylyltransferase, and mannose 1-phosphate guanylyltransferase (guanosine triphosphate). This enzyme participates in fructose and mannose metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2CU2.

[edit] References

IUBMB entry for 2.7.7.13
BRENDA references for 2.7.7.13 (Recommended.)
PubMed references for 2.7.7.13
PubMed Central references for 2.7.7.13
Google Scholar references for 2.7.7.13
Munch-Peterson A (1955). "Enzymatic synthesis and phosphorolysis of guanosine diphosphate mannose". Arch. Biochem. Biophys. 55: 592–593. doi:10.1016/0003-9861(55)90441-0.
PREISS J, WOOD E (1964). "SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. I. GUANOSINE DIPHOSPHATE MANNOSE PYROPHOSPHORYLASE: PURIFICATION AND PROPERTIES". J. Biol. Chem. 239: 3119–26. PMID 14245350.