Mannitol dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a mannitol dehydrogenase (EC 1.1.1.255) is an enzyme that catalyzes the chemical reaction

D-mannitol + NAD⁺ $\rightleftharpoons$ D-mannose + NADH + H⁺

Thus, the two substrates of this enzyme are D-mannitol and NAD⁺, whereas its 3 products are D-mannose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is mannitol:NAD+ 1-oxidoreductase. Other names in common use include MTD, and NAD+-dependent mannitol dehydrogenase.

[edit] References

IUBMB entry for 1.1.1.255
BRENDA references for 1.1.1.255 (Recommended.)
PubMed references for 1.1.1.255
PubMed Central references for 1.1.1.255
Google Scholar references for 1.1.1.255
Stoop JM, Pharr DM (1992). "Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots". Arch. Biochem. Biophys. 298: 612–9. doi:10.1016/0003-9861(92)90456-7. PMID 1416989.
Stoop JM, Williamson JD, Conkling MA, Pharr DM (1995). "Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures". Plant. Physiol. 108: 1219–25. doi:10.1104/pp.108.3.1219. PMID 7630943.
Williamson JD, Stoop JM, Massel MO, Conkling MA, Pharr DM (1995). "Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3". Proc. Natl. Acad. Sci. U. S. A. 92: 7148–52. doi:10.1073/pnas.92.16.7148. PMID 7638158.
Stoop, JMH, Chilton WS and Pharr DM (1996). "Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery". Phytochemistry 43: 1145–1150. doi:10.1016/S0031-9422(96)00423-2.