Manganism
From Wikipedia, the free encyclopedia
| Manganism Classification and external resources |
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| ICD-10 | T57.2 |
|---|---|
| ICD-9 | 985.2 |
| MeSH | D020149 |
Manganism or manganese poisoning is a toxic condition resulting from chronic exposure to manganese and first identified in 1837 by James Couper. In initial stages of manganism, neurological symptoms consist of reduced response speed, irritability, mood changes, and compulsive behaviors.[1] Upon protracted exposure symptoms are more prominent and resemble those of idiopathic Parkinson's disease, which it is often misdiagnosed as, although there are particular differences in both the symptoms (nature of tremors, for example), response to drugs such as Levadopa, and affected portion of the basal ganglia. Symptoms are also similar to Lou Gehrig's disease and multiple sclerosis.
Manganism has become an active issue in workplace safety as it has been the subject of numerous product liability lawsuits against manufacturers of arc welding supplies. In these lawsuits, welders have accused the manufacturers of failing to provide adequate warning that their products could cause welding fumes to contain dangerously high manganese concentrations that could lead welders to develop manganism.
[edit] References
- ^ Roth JA (2006). "Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination". Biol. Res. 39 (1): 45–57. PMID 16629164.
[edit] External references
- Lucchini et al., "Metals and Neurodegeneration" - Research paper on heavy metals poisoning
- Antonini., "Health Effects of Welding" - Critical review including manganese discussion from National Institute of Occupational Safety and Health (NIOSH)
- Welding and Manganese Poisoning - Safety Corner column in IBEW Journal regarding manganese and welding.
- AWS Study on Welding and Exposure to Manganese - Report of an independent study commissioned by the American Welding Society
- Welding Fume Product Liability - Viewpoint of plaintiffs on welding rod litigation
- Welding Rod Litigation Information Network - Viewpoint of defense on welding rod litigation
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