Manganese peroxidase

From Wikipedia, the free encyclopedia

In enzymology, a manganese peroxidase (EC 1.11.1.13) is an enzyme that catalyzes the chemical reaction

2 Mn(II) + 2 H⁺ + H₂O₂ $\rightleftharpoons$ 2 Mn(III) + 2 H₂O

The 3 substrates of this enzyme are Mn(II), H⁺, and H₂O₂, whereas its two products are Mn(III) and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is Mn(II):hydrogen-peroxide oxidoreductase. Other names in common use include peroxidase-M2, and Mn-dependent (NADH-oxidizing) peroxidase. It employs one cofactor, heme.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1MN1, 1MN2, 1YYD, 1YYG, 1YZP, and 1YZR.

[edit] References

IUBMB entry for 1.11.1.13
BRENDA references for 1.11.1.13 (Recommended.)
PubMed references for 1.11.1.13
PubMed Central references for 1.11.1.13
Google Scholar references for 1.11.1.13
Glenn JK, Akileswaran L, Gold MH (1986). "Mn(II) oxidation is the principal function of the extracellular Mn-peroxidase from Phanerochaete chrysosporium". Arch. Biochem. Biophys. 251: 688–96. doi:10.1016/0003-9861(86)90378-4. PMID 3800395.
Paszczynski A, Huynh VB, Crawford R (1986). "Comparison of ligninase-I and peroxidase-M2 from the white-rot fungus Phanerochaete chrysosporium". Arch. Biochem. Biophys. 244: 750–65. doi:10.1016/0003-9861(86)90644-2. PMID 3080953.
Wariishi H, Akileswaran L and Gold MH (1988). "Manganese peroxidase from the basidiomycete Phanerochaete chrysosporium: spectral characterization of the oxidized states and the catalytic cycle". Biochemistry 27: 5365–5370. doi:10.1021/bi00414a061.