Manchester score
From Wikipedia, the free encyclopedia
Manchester score is an indicator of prognosis in small cell lung cancer.[1][2] It is calculated from a number of physical and biochemical markers.
A patient with small cell lung cancer scores one point for each of the following: -
- Serum lactate dehydrogenase exceeds the upper limit of the reference range.
- Serum sodium concentration less than 132 mmol/l.
- Serum alkaline phosphatase over one-and-a-half times the upper limit of the reference range.
- Serum bicarbonate less than 24.
- Karnofsky performance status less than 60.
- Extensive stage disease.
[edit] Prognosis
| Manchester score | Prognostic group | Two year survival (%) |
|---|---|---|
| 0-1 | Good | 16.2 |
| 2-3 | Medium | 2.5 |
| 4 or more | Poor | 0 |
[edit] References
- ^ Cerny, T; Blair V, Anderson H et al. (1987). "Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients". International Journal of Cancer 39 (2): 146–149.
- ^ Kawahara, Masaaki; Masahiro Fukuoka, Nagahiro Saijo et al. (1996). "Prognostic factors and prognostic staging system for small cell lung cancer". Japanese Journal of Clinical Oncology 27 (3): 158–165. Oxford University Press. ISSN: 0368-2811.
- ^ Maestu, I; Pastor M, Gómez-Codina J et al. (Jun 1997). "Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients". Annals of Oncology 8 (6): 547–553.
