MAN1A1

From Wikipedia, the free encyclopedia

Mannosidase, alpha, class 1A, member 1

PDB rendering based on 1nxc.

Available structures: 1nxc

Identifiers

Symbol(s)

MAN1A1; HUMM3; HUMM9; MAN9

External IDs

OMIM: 604344 MGI: 104677 HomoloGene: 4316

Gene ontology
Molecular Function:	• mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • calcium ion binding • mannosidase activity • hydrolase activity, acting on glycosyl bonds
Cellular Component:	• membrane fraction • endoplasmic reticulum • ER-Golgi intermediate compartment • membrane • integral to membrane
Biological Process:	• protein amino acid glycosylation • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005907 (mRNA)
NP_005898 (protein)

NM_008548 (mRNA)
NP_032574 (protein)

Location

Chr 6: 119.54 - 119.71 Mb

Chr 10: 53.59 - 53.76 Mb

Pubmed search

[1]

[2]

Mannosidase, alpha, class 1A, member 1, also known as MAN1A1, is a human gene.^[1]

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1.

[edit] Further reading

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.". Biochimie 83 (8): 783-90. PMID 11530211.
Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.". Virology 187 (1): 377-82. PMID 1736542.
Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.". AIDS Res. Hum. Retroviruses 6 (3): 371-80. PMID 2187500.
Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.". Jpn. J. Med. Sci. Biol. 43 (3): 75-87. PMID 2283726.
Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.". J. Biol. Chem. 265 (18): 10373-82. PMID 2355006.
Stein BS, Engleman EG (1990). "Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex.". J. Biol. Chem. 265 (5): 2640-9. PMID 2406237.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384-8. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.". J. Virol. 63 (6): 2452-6. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.". J. Acquir. Immune Defic. Syndr. 2 (2): 163-9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.". AIDS Res. Hum. Retroviruses 3 (3): 265-82. PMID 2829950.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.". Biochem. Biophys. Res. Commun. 141 (1): 33-8. PMID 3099781.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248-52. PMID 3264072.
Bieberich E, Bause E (1995). "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein.". Eur. J. Biochem. 233 (2): 644-9. PMID 7588811.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.". J. Virol. 67 (1): 150-60. PMID 8093218.
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.". Biochemistry 32 (41): 11087-99. PMID 8218172.
Bause E, Bieberich E, Rolfs A, et al. (1993). "Molecular cloning and primary structure of Man9-mannosidase from human kidney.". Eur. J. Biochem. 217 (2): 535-40. PMID 8223597.
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213-20. PMID 8673525.
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.". J. Virol. 70 (11): 7462-70. PMID 8892864.
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.". FEBS Lett. 406 (1-2): 191-5. PMID 9109416.
Bieberich E, Treml K, Völker C, et al. (1997). "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells.". Eur. J. Biochem. 246 (3): 681-9. PMID 9219526.