MAML2

From Wikipedia, the free encyclopedia

Mastermind-like 2 (Drosophila)

Identifiers

MAML2; MAM2; DKFZp686N0150; KIAA1819; MAM-3; MAM3; MLL-MAML2

External IDs

OMIM: 607537 MGI: 2389460 HomoloGene: 41868

Gene ontology
Molecular Function:	• transcription coactivator activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_032427 (mRNA)
NP_115803 (protein)

XM_486185 (mRNA)
XP_486185 (protein)

Location

Chr 11: 95.35 - 95.47 Mb

Chr 9: 13.37 - 13.46 Mb

Pubmed search

[1]

[2]

Mastermind-like 2 (Drosophila), also known as MAML2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MAML2 mastermind-like 2 (Drosophila).

[edit] Further reading

Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906.
Wu L, Sun T, Kobayashi K, et al. (2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.". Mol. Cell. Biol. 22 (21): 7688–700. PMID 12370315.
Lin SE, Oyama T, Nagase T, et al. (2003). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling.". J. Biol. Chem. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tonon G, Modi S, Wu L, et al. (2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.". Nat. Genet. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049.
Enlund F, Behboudi A, Andrén Y, et al. (2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.". Exp. Cell Res. 292 (1): 21–8. PMID 14720503.
Behboudi A, Winnes M, Gorunova L, et al. (2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.". Genes Chromosomes Cancer 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701.
Wu L, Liu J, Gao P, et al. (2005). "Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.". EMBO J. 24 (13): 2391–402. doi:10.1038/sj.emboj.7600719. PMID 15961999.
Okabe M, Miyabe S, Nagatsuka H, et al. (2007). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma.". Clin. Cancer Res. 12 (13): 3902–7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685.
Winnes M, Mölne L, Suurküla M, et al. (2007). "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas.". Genes Chromosomes Cancer 46 (6): 559–63. doi:10.1002/gcc.20440. PMID 17334997.
Tirado Y, Williams MD, Hanna EY, et al. (2007). "CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior.". Genes Chromosomes Cancer 46 (7): 708–15. doi:10.1002/gcc.20458. PMID 17437281.
Nemoto N, Suzukawa K, Shimizu S, et al. (2007). "Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23).". Genes Chromosomes Cancer 46 (9): 813–9. doi:10.1002/gcc.20467. PMID 17551948.