Malyl-CoA lyase

From Wikipedia, the free encyclopedia

In enzymology, a malyl-CoA lyase (EC 4.1.3.24) is an enzyme that catalyzes the chemical reaction

(3S)-3-carboxy-3-hydroxypropanoyl-CoA acetyl-CoA + glyoxylate

Hence, this enzyme has one substrate, (3S)-3-carboxy-3-hydroxypropanoyl-CoA, and two products, acetyl-CoA and glyoxylate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming). Other names in common use include malyl-coenzyme A lyase, and (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

[edit] References

• IUBMB entry for 4.1.3.24
• BRENDA references for 4.1.3.24 (Recommended.)
• PubMed references for 4.1.3.24
• PubMed Central references for 4.1.3.24
• Google Scholar references for 4.1.3.24
• Tuboi S and Kikuchi G (1965). "Enzymic cleavage of malyl-Coenzyme A into acetyl-Coenzyme A and glyoxylic acid". Biochim. Biophys. Acta 96: 148–153. 

[edit] External links

The CAS registry number for this enzyme class is 37290-67-8.

• IUBMB entry for 4.1.3.24

• KEGG entry for 4.1.3.24

• BRENDA entry for 4.1.3.24

• NiceZyme view of 4.1.3.24

• EC2PDB: PDB structures for 4.1.3.24

• PRIAM entry for 4.1.3.24

• PUMA2 entry for 4.1.3.24

• IntEnz: Integrated Enzyme entry for 4.1.3.24

• MetaCyc entry for 4.1.3.24

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050083: malyl-CoA lyase

• AMIGO entry for GO code 0050083: malyl-CoA lyase