Malonate-semialdehyde dehydrogenase

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In enzymology, a malonate-semialdehyde dehydrogenase (EC 1.2.1.15) is an enzyme that catalyzes the chemical reaction

3-oxopropanoate + NAD(P)+ + H₂O malonate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are 3-oxopropanoate, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are malonate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase. This enzyme participates in beta-alanine metabolism.

[edit] References

• IUBMB entry for 1.2.1.15
• BRENDA references for 1.2.1.15 (Recommended.)
• PubMed references for 1.2.1.15
• PubMed Central references for 1.2.1.15
• Google Scholar references for 1.2.1.15
• Nakamura K and Bernheim F (1961). "Studies on malonic semialdehyde dehydrogenase from Pseudomonas aeruginosa". Biochim. Biophys. Acta 50: 147–152. doi:10.1016/0006-3002(61)91071-X. 

[edit] External links

The CAS registry number for this enzyme class is 9028-94-8.

• IUBMB entry for 1.2.1.15

• KEGG entry for 1.2.1.15

• BRENDA entry for 1.2.1.15

• NiceZyme view of 1.2.1.15

• EC2PDB: PDB structures for 1.2.1.15

• PRIAM entry for 1.2.1.15

• PUMA2 entry for 1.2.1.15

• IntEnz: Integrated Enzyme entry for 1.2.1.15

• MetaCyc entry for 1.2.1.15

• Atomic-resolution structures of enzymes belonging to this class