Mallory body

From Wikipedia, the free encyclopedia

Mallory bodies (also known as "alcoholic hyaline" or "Mallory's hyaline) are pathologic inclusions found in the cytoplasm of liver cells. They are most commonly found in the livers of people suffering from alcoholic hepatitis. They are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate keratin filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62.

Mallory bodies may also be seen in Wilson's disease, primary biliary cirrhosis, chronic cholestatic syndromes, focal nodular hyperplasia and hepatocellular carcinoma.