Malate oxidase

From Wikipedia, the free encyclopedia

In enzymology, a malate oxidase (EC 1.1.3.3) is an enzyme that catalyzes the chemical reaction

(S)-malate + O₂ oxaloacetate + H₂O₂

Thus, the two substrates of this enzyme are (S)-malate and O₂, whereas its two products are oxaloacetate and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-malate:oxygen oxidoreductase. Other names in common use include FAD-dependent malate oxidase, malic oxidase, and malic dehydrogenase II. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

[edit] References

• IUBMB entry for 1.1.3.3
• BRENDA references for 1.1.3.3 (Recommended.)
• PubMed references for 1.1.3.3
• PubMed Central references for 1.1.3.3
• Google Scholar references for 1.1.3.3
• COHN DV (1958). "The enzymatic formation of oxalacetic acid by nonpyridine nucleotide malic dehydrogenase of Micrococcus lysodeikticus". J. Biol. Chem. 233: 299–304. PMID 13563491. 
• Narindrasorasak S, Goldie AH, Sanwal BD (1979). "Characteristics and regulation of a phospholipid-activated malate oxidase from Escherichia coli". J. Biol. Chem. 254: 1540–5. PMID 368072. 

[edit] External links

The CAS registry number for this enzyme class is 9028-73-3.

• IUBMB entry for 1.1.3.3

• KEGG entry for 1.1.3.3

• BRENDA entry for 1.1.3.3

• NiceZyme view of 1.1.3.3

• EC2PDB: PDB structures for 1.1.3.3

• PRIAM entry for 1.1.3.3

• PUMA2 entry for 1.1.3.3

• IntEnz: Integrated Enzyme entry for 1.1.3.3

• MetaCyc entry for 1.1.3.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019157: malate oxidase

• AMIGO entry for GO code 0019157: malate oxidase