Malate dehydrogenase 2

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Malate dehydrogenase 2, NAD (mitochondrial)
PDB rendering based on 1mld.
Available structures: 1mld, 2dfd
Identifiers
Symbol(s)	MDH2; M-MDH; MDH; MGC:3559; MOR1
External IDs	OMIM: 154100 MGI: 97050 HomoloGene: 55938
EC number	1.1.1.37
Gene ontology Molecular Function: • L-lactate dehydrogenase activity • oxidoreductase activity • L-malate dehydrogenase activity Cellular Component: • mitochondrion • mitochondrial matrix Biological Process: • glycolysis • tricarboxylic acid cycle • malate metabolic process • biological_process
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4191	17448
Ensembl	ENSG00000146701	ENSMUSG00000019179
Uniprot	P40926	Q0QF44
Refseq	NM_005918 (mRNA) NP_005909 (protein)	NM_008617 (mRNA) NP_032643 (protein)
Location	Chr 7: 75.52 - 75.53 Mb	Chr 5: 136.06 - 136.08 Mb
Pubmed search	[1]	[2]

Malate dehydrogenase 2, NAD (mitochondrial), also known as MDH2, is a human gene.

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.^[1]

[edit] See also

• Malate dehydrogenase

[edit] References