Malate dehydrogenase (decarboxylating)

From Wikipedia, the free encyclopedia

In enzymology, a malate dehydrogenase (decarboxylating) (EC 1.1.1.39) is an enzyme that catalyzes the chemical reaction

(S)-malate + NAD⁺ pyruvate + CO₂ + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD⁺, whereas its 3 products are pyruvate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (decarboxylating). Other names in common use include 'malic' enzyme, pyruvic-malic carboxylase, NAD+-specific malic enzyme, and NAD+-malic enzyme. This enzyme participates in pyruvate metabolism and carbon fixation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1DO8, 1EFK, 1EFL, 1PJ2, 1PJ3, 1PJ4, and 1QR6.

[edit] References

• IUBMB entry for 1.1.1.39
• BRENDA references for 1.1.1.39 (Recommended.)
• PubMed references for 1.1.1.39
• PubMed Central references for 1.1.1.39
• Google Scholar references for 1.1.1.39
• Saz HJ and Hubbard JA (1957). "The oxidative decarboxylation of malate by Ascoris lumbricoides". J. Biol. Chem. 225: 921–933. 

[edit] External links

The CAS registry number for this enzyme class is 9028-46-0.

• IUBMB entry for 1.1.1.39

• KEGG entry for 1.1.1.39

• BRENDA entry for 1.1.1.39

• NiceZyme view of 1.1.1.39

• EC2PDB: PDB structures for 1.1.1.39

• PRIAM entry for 1.1.1.39

• PUMA2 entry for 1.1.1.39

• IntEnz: Integrated Enzyme entry for 1.1.1.39

• MetaCyc entry for 1.1.1.39

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004471: malate dehydrogenase (decarboxylating)

• AMIGO entry for GO code 0004471: malate dehydrogenase (decarboxylating)