Malate dehydrogenase (acceptor)

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In enzymology, a malate dehydrogenase (acceptor) (EC 1.1.99.16) is an enzyme that catalyzes the chemical reaction

(S)-malate + acceptor $\rightleftharpoons$ oxaloacetate + reduced acceptor

Thus, the two substrates of this enzyme are (S)-malate and acceptor, whereas its two products are oxaloacetate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-malate:acceptor oxidoreductase. Other names in common use include FAD-dependent malate-vitamin K reductase, malate-vitamin K reductase, and (S)-malate:(acceptor) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

[edit] References

IUBMB entry for 1.1.99.16
BRENDA references for 1.1.99.16 (Recommended.)
PubMed references for 1.1.99.16
PubMed Central references for 1.1.99.16
Google Scholar references for 1.1.99.16
Imai D and Brodie AF (1973). "A phospholipid-requiring enzyme, malate-vitamin K reductase". J. Biol. Chem. 248: 7487–7494.
Imai T (1978). "FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties". Biochim. Biophys. Acta. 523: 37–46. PMID 629992.
Prasada Reddy TL, Suryanarayana Murthy P, Venkitasubramanian TA (1975). "Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria". Biochim. Biophys. Acta. 376: 210–8. PMID 234747.