Malate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, a malate-CoA ligase (EC 6.2.1.9) is an enzyme that catalyzes the chemical reaction

ATP + malate + CoA ADP + phosphate + malyl-CoA

The 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is malate:CoA ligase (ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

[edit] References

• IUBMB entry for 6.2.1.9
• BRENDA references for 6.2.1.9 (Recommended.)
• PubMed references for 6.2.1.9
• PubMed Central references for 6.2.1.9
• Google Scholar references for 6.2.1.9
• Mue S, Tuboi S and Kikuchi G (Tokyo). "On malyl-coenzyme A synthetase". J. Biochem.: 545–551. 

[edit] External links

The CAS registry number for this enzyme class is 37318-58-4.

• IUBMB entry for 6.2.1.9

• KEGG entry for 6.2.1.9

• BRENDA entry for 6.2.1.9

• NiceZyme view of 6.2.1.9

• EC2PDB: PDB structures for 6.2.1.9

• PRIAM entry for 6.2.1.9

• PUMA2 entry for 6.2.1.9

• IntEnz: Integrated Enzyme entry for 6.2.1.9

• MetaCyc entry for 6.2.1.9

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050074: malate-CoA ligase

• AMIGO entry for GO code 0050074: malate-CoA ligase