MALT1

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Mucosa associated lymphoid tissue lymphoma translocation gene 1
PDB rendering based on 2g7r.
Available structures: 2g7r
Identifiers
Symbol(s)	MALT1; DKFZp434L132; MLT; MLT1
External IDs	OMIM: 604860 MGI: 2445027 HomoloGene: 4938
EC number	3.4.22.-
Gene ontology Molecular Function: • ubiquitin-protein ligase activity • signal transducer activity • peptidase activity • kinase activator activity • caspase activity • protein self-association Cellular Component: • nucleus • cytoplasm • CBM complex Biological Process: • positive regulation of T cell cytokine production • proteolysis • ubiquitin cycle • anti-apoptosis • defense response • activation of NF-kappaB-inducing kinase • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • T cell receptor signaling pathway • positive regulation of T cell activation • nuclear export • protein oligomerization
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	10892	240354
Ensembl	ENSG00000172175	ENSMUSG00000032688
Uniprot	Q9UDY8	Q8BRB5
Refseq	NM_006785 (mRNA) NP_006776 (protein)	NM_172833 (mRNA) NP_766421 (protein)
Location	Chr 18: 54.49 - 54.57 Mb	Chr 18: 65.56 - 65.6 Mb
Pubmed search	[1]	[2]

Mucosa associated lymphoid tissue lymphoma translocation gene 1, also known as MALT1, is a human gene.

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] See also

• Paracaspase

[edit] References

[edit] Further reading