MAK (gene)

From Wikipedia, the free encyclopedia

Male germ cell-associated kinase

Identifiers

MAK; dJ417M14.2

External IDs

OMIM: 154235 MGI: 96913 HomoloGene: 31344

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • multicellular organismal development • spermatogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005906 (mRNA)
NP_005897 (protein)

NM_008547 (mRNA)
NP_032573 (protein)

Location

Chr 6: 10.87 - 10.95 Mb

Chr 13: 41.04 - 41.09 Mb

Pubmed search

[1]

[2]

Male germ cell-associated kinase, also known as MAK, is a human gene.^[1]

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAK male germ cell-associated kinase.

[edit] Further reading

Koji T, Jinno A, Matsushime H, et al. (1993). "In situ localization of male germ cell-associated kinase (mak) mRNA in adult mouse testis: specific expression in germ cells at stages around meiotic cell division.". Cell Biochem. Funct. 10 (4): 273–9. doi:10.1002/cbf.290100411. PMID 1473268.
Matsushime H, Jinno A, Takagi N, Shibuya M (1990). "A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis.". Mol. Cell. Biol. 10 (5): 2261–8. PMID 2183027.
Taketo M, Jinno A, Yamaguchi S, et al. (1994). "Mouse Mak gene for male germ cell-associated kinase maps to chromosome 13.". Genomics 19 (2): 397–8. doi:10.1006/geno.1994.1082. PMID 8188277.
Jinno A, Tanaka K, Matsushime H, et al. (1993). "Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated with a 210-kilodalton cellular phosphoprotein.". Mol. Cell. Biol. 13 (7): 4146–56. PMID 8321219.
Bladt F, Birchmeier C (1993). "Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells.". Differentiation 53 (2): 115–22. PMID 8359591.
Xia L, Robinson D, Ma AH, et al. (2002). "Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.". J. Biol. Chem. 277 (38): 35422–33. doi:10.1074/jbc.M203940200. PMID 12084720.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ma AH, Xia L, Desai SJ, et al. (2007). "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.". Cancer Res. 66 (17): 8439–47. doi:10.1158/0008-5472.CAN-06-1636. PMID 16951154.
Fu Z, Larson KA, Chitta RK, et al. (2007). "Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase.". Mol. Cell. Biol. 26 (22): 8639–54. doi:10.1128/MCB.00816-06. PMID 16954377.