Major vault protein

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Major vault protein
PDB rendering based on 1y7x.
Available structures: 1y7x
Identifiers
Symbol(s) MVP; LRP; VAULT1
External IDs OMIM: 605088 MGI: 1925638 HomoloGene: 3752
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9961 78388
Ensembl ENSG00000013364 ENSMUSG00000030681
Uniprot Q14764 Q3THX5
Refseq NM_005115 (mRNA)
NP_005106 (protein)		 NM_080638 (mRNA)
NP_542369 (protein)
Location Chr 16: 29.74 - 29.77 Mb Chr 7: 126.78 - 126.81 Mb
Pubmed search [1] [2]

Major vault protein, also known as MVP, is a human gene.[1]

This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[1]

[edit] References

  1. ^ a b Entrez Gene: MVP major vault protein.

[edit] Further reading

  • Izquierdo MA, Scheffer GL, Flens MJ, et al. (1996). "Major vault protein LRP-related multidrug resistance.". Eur. J. Cancer 32A (6): 979–84. PMID 8763338. 
  • Scheffer GL, Wijngaard PL, Flens MJ, et al. (1995). "The drug resistance-related protein LRP is the human major vault protein.". Nat. Med. 1 (6): 578–82. PMID 7585126. 
  • Slovak ML, Ho JP, Cole SP, et al. (1995). "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification.". Cancer Res. 55 (19): 4214–9. PMID 7671223. 
  • Izquierdo MA, Scheffer GL, Flens MJ, et al. (1997). "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.". Am. J. Pathol. 148 (3): 877–87. PMID 8774142. 
  • Dingemans AM, van Ark-Otte J, van der Valk P, et al. (1997). "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues.". Ann. Oncol. 7 (6): 625–30. PMID 8879378. 
  • Sugawara I, Akiyama S, Scheper RJ, Itoyama S (1997). "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP.". Cancer Lett. 112 (1): 23–31. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166. 
  • Abbondanza C, Rossi V, Roscigno A, et al. (1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell.". J. Cell Biol. 141 (6): 1301–10. PMID 9628887. 
  • Ikeda K, Oka M, Yamada Y, et al. (1999). "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes.". Int. J. Cancer 82 (4): 599–604. PMID 10404077. 
  • Rimsza LM, Campbell K, Dalton WS, et al. (1999). "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma.". Leuk. Lymphoma 34 (3-4): 315–24. PMID 10439368. 
  • Kickhoefer VA, Siva AC, Kedersha NL, et al. (1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.". J. Cell Biol. 146 (5): 917–28. PMID 10477748. 
  • Kickhoefer VA, Stephen AG, Harrington L, et al. (2000). "Vaults and telomerase share a common subunit, TEP1.". J. Biol. Chem. 274 (46): 32712–7. PMID 10551828. 
  • Lange C, Walther W, Schwabe H, Stein U (2001). "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter.". Biochem. Biophys. Res. Commun. 278 (1): 125–33. doi:10.1006/bbrc.2000.3782. PMID 11071864. 
  • Holzmann K, Ambrosch I, Elbling L, et al. (2001). "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant.". FEBS Lett. 494 (1-2): 99–104. PMID 11297743. 
  • van Zon A, Mossink MH, Schoester M, et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly.". Biochem. Biophys. Res. Commun. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821. 
  • Sakaki Y, Terashi K, Yamaguchi A, et al. (2002). "Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient.". Exp. Hematol. 30 (4): 340–5. PMID 11937269. 
  • Zhao Y, Yu L, Wang Q, et al. (2002). "[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]". Zhonghua Nei Ke Za Zhi 41 (3): 183–5. PMID 11940320. 
  • Scheffer GL, Pijnenborg AC, Smit EF, et al. (2002). "Multidrug resistance related molecules in human and murine lung.". J. Clin. Pathol. 55 (5): 332–9. PMID 11986335. 
  • van den Heuvel-Eibrink MM, Wiemer EA, Prins A, et al. (2002). "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML).". Leukemia 16 (5): 833–9. doi:10.1038/sj.leu.2402496. PMID 11986944. 
  • Yu Z, Fotouhi-Ardakani N, Wu L, et al. (2002). "PTEN associates with the vault particles in HeLa cells.". J. Biol. Chem. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006. 
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