Mainframe
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Mainframe may refer to one of the following:
- Mainframe computer, large data processing systems
- Mainframe Entertainment, a Canadian computer animation and design company.
- Mainframe is the city that the CGI cartoon ReBoot takes place in.
- Mainframe (band), a 1980s Electropop band
- Mainframe is the name of two fictional characters from Marvel Comics
- Mainframe (comics) appears in the series A-Next
- Mainframe appears in the Guardians of the Galaxy series
- Mainframe (Transformers) is An Autobot character in the Transformers series.
- A character in the G.I. Joe universe.
- A character from the game Gunman Chronicles.