Magnesium chelatase

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In enzymology, a magnesium chelatase (EC 6.6.1.1) is an enzyme that catalyzes the chemical reaction

ATP + protoporphyrin IX + Mg₂+ + H₂O $\rightleftharpoons$ ADP + phosphate + Mg-protoporphyrin IX + 2 H⁺

The 4 substrates of this enzyme are ATP, protoporphyrin IX, Mg2+, and H₂O, whereas its 4 products are ADP, phosphate, Mg-protoporphyrin IX, and H⁺.

This enzyme belongs to the family of ligases, specifically those forming nitrogen-D-metal bonds in coordination complexes. The systematic name of this enzyme class is Mg-protoporphyrin IX magnesium-lyase. Other names in common use include protoporphyrin IX magnesium-chelatase, protoporphyrin IX Mg-chelatase, magnesium-protoporphyrin IX chelatase, magnesium-protoporphyrin chelatase, magnesium-chelatase, Mg-chelatase, and Mg-protoporphyrin IX magnesio-lyase. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

IUBMB entry for 6.6.1.1
BRENDA references for 6.6.1.1 (Recommended.)
PubMed references for 6.6.1.1
PubMed Central references for 6.6.1.1
Google Scholar references for 6.6.1.1
Walker CJ, Weinstein JD (1991). "In vitro assay of the chlorophyll biosynthetic enzyme Mg-chelatase: resolution of the activity into soluble and membrane-bound fractions". Proc. Natl. Acad. Sci. U. S. A. 88: 5789–93. doi:10.1073/pnas.88.13.5789. PMID 11607197.
Walker CJ, Willows RD (Pt 2). "Mechanism and regulation of Mg-chelatase". Biochem. J. 327: 321–33. PMID 9359397.
Al-Karadaghi S (2001). "Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase". J. Mol. Biol. 311: 111–22. doi:10.1006/jmbi.2001.4834. PMID 11469861.