MAGI2

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Membrane associated guanylate kinase, WW and PDZ domain containing 2
PDB rendering based on 1uep.
Available structures: 1uep, 1ueq, 1uew, 1ujv, 1wfv
Identifiers
Symbol(s) MAGI2; AIP1; ACVRIP1; ARIP1; MAGI-2
External IDs OMIM: 606382 MGI: 1354953 HomoloGene: 8189
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9863 50791
Ensembl ENSG00000187391 ENSMUSG00000040003
Uniprot Q86UL8 Q9WVQ1
Refseq NM_012301 (mRNA)
NP_036433 (protein)		 XM_001000863 (mRNA)
XP_001000863 (protein)
Location Chr 7: 77.49 - 78.92 Mb Chr 5: 18.74 - 20.17 Mb
Pubmed search [1] [2]

Membrane associated guanylate kinase, WW and PDZ domain containing 2, also known as MAGI2, is a human gene.[1]

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.[1]

[edit] References

  1. ^ a b Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2.

[edit] Further reading

  • Wood JD, Yuan J, Margolis RL, et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693. 
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074. 
  • Ide N, Hata Y, Deguchi M, et al. (1999). "Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.". Biochem. Biophys. Res. Commun. 256 (3): 456–61. doi:10.1006/bbrc.1999.0364. PMID 10080919. 
  • Shoji H, Tsuchida K, Kishi H, et al. (2000). "Identification and characterization of a PDZ protein that interacts with activin type II receptors.". J. Biol. Chem. 275 (8): 5485–92. PMID 10681527. 
  • Wu X, Hepner K, Castelino-Prabhu S, et al. (2000). "Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4233–8. PMID 10760291. 
  • Xu J, Paquet M, Lau AG, et al. (2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.". J. Biol. Chem. 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121. 
  • Vazquez F, Grossman SR, Takahashi Y, et al. (2002). "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.". J. Biol. Chem. 276 (52): 48627–30. doi:10.1074/jbc.C100556200. PMID 11707428. 
  • Nishimura W, Yao I, Iida J, et al. (2002). "Interaction of synaptic scaffolding molecule and Beta -catenin.". J. Neurosci. 22 (3): 757–65. PMID 11826105. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yap CC, Muto Y, Kishida H, et al. (2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein.". Biochem. Biophys. Res. Commun. 301 (4): 1122–8. PMID 12589829. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Evgrafov OV, Mersiyanova I, Irobi J, et al. (2004). "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.". Nat. Genet. 36 (6): 602–6. doi:10.1038/ng1354. PMID 15122254. 
  • Franklin JL, Yoshiura K, Dempsey PJ, et al. (2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein.". Exp. Cell Res. 303 (2): 457–70. doi:10.1016/j.yexcr.2004.10.007. PMID 15652357. 
  • Hu Y, Li Z, Guo L, et al. (2007). "MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells.". Arch. Biochem. Biophys. 467 (1): 1–9. doi:10.1016/j.abb.2007.07.027. PMID 17880912. 
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