MAGED2

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Melanoma antigen family D, 2
Identifiers
Symbol(s) MAGED2; 11B6; BCG1; HCA10; JCL-1; MAGE-D2; MAGED; MGC8386
External IDs OMIM: 300470 MGI: 1933391 HomoloGene: 12750
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10916 80884
Ensembl ENSG00000102316 ENSMUSG00000025268
Uniprot Q9UNF1 n/a
Refseq NM_014599 (mRNA)
NP_055414 (protein)		 XM_978661 (mRNA)
XP_983755 (protein)
Location Chr X: 54.85 - 54.86 Mb Chr X: 146.15 - 146.15 Mb
Pubmed search [1] [2]

Melanoma antigen family D, 2, also known as MAGED2, is a human gene.[1]

This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined.[1]

[edit] References

  1. ^ a b Entrez Gene: MAGED2 melanoma antigen family D, 2.

[edit] Further reading

  • Lucas S, Brasseur F, Boon T (1999). "A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells.". Cancer Res. 59 (16): 4100–3. PMID 10463614. 
  • Kurt RA, Urba WJ, Schoof DD (2000). "Isolation of genes overexpressed in freshly isolated breast cancer specimens.". Breast Cancer Res. Treat. 59 (1): 41–8. PMID 10752678. 
  • Langnaese K, Kloos DU, Wehnert M, et al. (2002). "Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues.". Cytogenet. Cell Genet. 94 (3-4): 233–40. PMID 11856887. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Bertrand M, Huijbers I, Chomez P, De Backer O (2005). "Comparative expression analysis of the MAGED genes during embryogenesis and brain development.". Dev. Dyn. 230 (2): 325–34. doi:10.1002/dvdy.20026. PMID 15162511. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Harper R, Xu C, Di P, et al. (2004). "Identification of a novel MAGE D2 antisense RNA transcript in human tissues.". Biochem. Biophys. Res. Commun. 324 (1): 199–204. doi:10.1016/j.bbrc.2004.09.037. PMID 15465002. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Papageorgio C, Brachmann R, Zeng J, et al. (2007). "MAGED2: a novel p53-dissociator.". Int. J. Oncol. 31 (5): 1205–11. PMID 17912449. 
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