MAGEA12

From Wikipedia, the free encyclopedia

Melanoma antigen family A, 12

Identifiers

External IDs

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• cellular_component
Biological Process:	• biological_process

Orthologs

Human

Mouse

Entrez

4111

n/a

Refseq

NM_005367 (mRNA)
NP_005358 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Melanoma antigen family A, 12, also known as MAGEA12, is a human gene.^[1]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAGEA12 melanoma antigen family A, 12.

[edit] Further reading

De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family.". Immunogenetics 40 (5): 360-9. PMID 7927540.
Ding M, Beck RJ, Keller CJ, Fenton RG (1994). "Cloning and analysis of MAGE-1-related genes.". Biochem. Biophys. Res. Commun. 202 (1): 549-55. doi:10.1006/bbrc.1994.1963. PMID 8037761.
De Smet C, Lurquin C, van der Bruggen P, et al. (1994). "Sequence and expression pattern of the human MAGE2 gene.". Immunogenetics 39 (2): 121-9. PMID 8276455.
Rogner UC, Wilke K, Steck E, et al. (1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.". Genomics 29 (3): 725-31. doi:10.1006/geno.1995.9945. PMID 8575766.
Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.". Genome Res. 10 (6): 758-75. PMID 10854409.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Wischnewski F, Friese O, Pantel K, Schwarzenbach H (2007). "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.". Mol. Cancer Res. 5 (7): 749-59. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.