MAGEA11

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Melanoma antigen family A, 11
Identifiers
Symbol(s) MAGEA11; MAGE-11; MAGE11; MAGEA-11; MGC10511
External IDs OMIM: 300344 MGI: 1333834 HomoloGene: 23188
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4110 17137
Ensembl ENSG00000185247 ENSMUSG00000059539
Uniprot P43364 n/a
Refseq NM_001011544 (mRNA)
NP_001011544 (protein)		 XM_001006950 (mRNA)
XP_001006950 (protein)
Location Chr X: 148.58 - 148.65 Mb Chr X: 150.43 - 150.43 Mb
Pubmed search [1] [2]

Melanoma antigen family A, 11, also known as MAGEA11, is a human gene.[1]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: MAGEA11 melanoma antigen family A, 11.

[edit] Further reading

  • De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family.". Immunogenetics 40 (5): 360–9. PMID 7927540. 
  • Rogner UC, Wilke K, Steck E, et al. (1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.". Genomics 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766. 
  • Jurk M, Kremmer E, Schwarz U, et al. (1998). "MAGE-11 protein is highly conserved in higher organisms and located predominantly in the nucleus.". Int. J. Cancer 75 (5): 762–6. PMID 9495246. 
  • Serrano A, Lethé B, Delroisse JM, et al. (1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries.". Int. J. Cancer 83 (5): 664–9. PMID 10521804. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Bai S, He B, Wilson EM (2005). "Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.". Mol. Cell. Biol. 25 (4): 1238–57. doi:10.1128/MCB.25.4.1238-1257.2005. PMID 15684378. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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