MAF1

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MAF1 homolog (S. cerevisiae)
Identifiers
Symbol(s) MAF1; MGC20332; MGC31779; MGC39758
External IDs OMIM: 610210 MGI: 1916127 HomoloGene: 49867
Orthologs
Human Mouse
Entrez 84232 68877
Ensembl ENSG00000179632 ENSMUSG00000022553
Uniprot Q9H063 Q9D0U6
Refseq NM_032272 (mRNA)
NP_115648 (protein)		 NM_026859 (mRNA)
NP_081135 (protein)
Location Chr 8: 145.23 - 145.23 Mb Chr 15: 76.18 - 76.18 Mb
Pubmed search [1] [2]

MAF1 homolog (S. cerevisiae), also known as MAF1, is a human gene.[1]

This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.[1]

[edit] References

  1. ^ a b Entrez Gene: MAF1 MAF1 homolog (S. cerevisiae).

[edit] Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Pluta K, Lefebvre O, Martin NC, et al. (2001). "Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae.". Mol. Cell. Biol. 21 (15): 5031–40. doi:10.1128/MCB.21.15.5031-5040.2001. PMID 11438659. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Upadhya R, Lee J, Willis IM (2003). "Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription.". Mol. Cell 10 (6): 1489–94. PMID 12504022. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.". Mol. Cell 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043. 
  • Rollins J, Veras I, Cabarcas S, et al. (2007). "Human Maf1 negatively regulates RNA polymerase III transcription via the TFIIB family members Brf1 and Brf2.". Int. J. Biol. Sci. 3 (5): 292–302. PMID 17505538. 
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