MADD (gene)

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MAP-kinase activating death domain
Identifiers
Symbol(s) MADD; DENN; IG20; KIAA0358; RAB3GEP
External IDs OMIM: 603584 MGI: 2444672 HomoloGene: 14249
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8567 228355
Ensembl ENSG00000110514 ENSMUSG00000040687
Refseq NM_003682 (mRNA)
NP_003673 (protein)		 NM_145527 (mRNA)
NP_663502 (protein)
Location Chr 11: 47.25 - 47.31 Mb Chr 2: 90.94 - 90.98 Mb
Pubmed search [1] [2]

MAP-kinase activating death domain, also known as MADD, is a human gene.[1]

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: MADD MAP-kinase activating death domain.

[edit] Further reading

  • Chow VT, Lee SS (1997). "DENN, a novel human gene differentially expressed in normal and neoplastic cells.". DNA Seq. 6 (5): 263-73. PMID 8988362. 
  • Schievella AR, Chen JH, Graham JR, Lin LL (1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.". J. Biol. Chem. 272 (18): 12069-75. PMID 9115275. 
  • Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141-50. PMID 9205841. 
  • Zhang Y, Zhou L, Miller CA (1998). "A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2586-91. PMID 9482930. 
  • Chow VT, Lim KM, Lim D (1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22.". Genome 41 (4): 543-52. PMID 9796103. 
  • Suzuki Y, Ishihara D, Sasaki M, et al. (2000). "Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries.". Genomics 64 (3): 286-97. doi:10.1006/geno.2000.6076. PMID 10756096. 
  • Telliez JB, Bean KM, Lin LL (2000). "LRDD, a novel leucine rich repeat and death domain containing protein.". Biochim. Biophys. Acta 1478 (2): 280-8. PMID 10825539. 
  • Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission.". EMBO J. 19 (17): 4806-16. doi:10.1093/emboj/19.17.4806. PMID 10970871. 
  • Al-Zoubi AM, Efimova EV, Kaithamana S, et al. (2002). "Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.". J. Biol. Chem. 276 (50): 47202-11. doi:10.1074/jbc.M104835200. PMID 11577081. 
  • Lim KM, Chow VT (2002). "Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells).". Mol. Carcinog. 35 (3): 110-26. doi:10.1002/mc.10082. PMID 12410563. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Efimova E, Martinez O, Lokshin A, et al. (2004). "IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.". Cancer Res. 63 (24): 8768-76. PMID 14695193. 
  • Efimova EV, Al-Zoubi AM, Martinez O, et al. (2004). "IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.". Oncogene 23 (5): 1076-87. doi:10.1038/sj.onc.1207210. PMID 14716293. 
  • Lim KM, Yeo WS, Chow VT (2004). "Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle.". Int. J. Cancer 109 (1): 24-37. doi:10.1002/ijc.11660. PMID 14735464. 
  • Del Villar K, Miller CA (2004). "Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons.". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4210-5. doi:10.1073/pnas.0307349101. PMID 15007167. 
  • Xu Y, Kulkosky J, Acheampong E, et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy.". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070-5. doi:10.1073/pnas.0304859101. PMID 15103018. 
  • Ramaswamy M, Efimova EV, Martinez O, et al. (2005). "IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC.". Oncogene 23 (36): 6083-94. doi:10.1038/sj.onc.1207804. PMID 15208670. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hu YF, Zhang HL, Cai T, et al. (2006). "The IA-2 interactome.". Diabetologia 48 (12): 2576-81. doi:10.1007/s00125-005-0037-y. PMID 16273344. 
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