MAD2L1BP

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MAD2L1 binding protein
Identifiers
Symbol(s) MAD2L1BP; CMT2; KIAA0110; MGC11282; RP1-261G23.6
External IDs MGI: 1913841 HomoloGene: 11990
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9587 66591
Ensembl ENSG00000124688 ENSMUSG00000034509
Uniprot Q15013 Q3U0U3
Refseq NM_001003690 (mRNA)
NP_001003690 (protein)		 NM_025649 (mRNA)
NP_079925 (protein)
Location Chr 6: 43.71 - 43.72 Mb Chr 17: 45.61 - 45.62 Mb
Pubmed search [1] [2]

MAD2L1 binding protein, also known as MAD2L1BP, is a human gene.[1]

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]

[edit] References

  1. ^ a b Entrez Gene: MAD2L1BP MAD2L1 binding protein.

[edit] Further reading

  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527. 
  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595. 
  • Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653. 
  • Habu T, Kim SH, Weinstein J, Matsumoto T (2003). "Identification of a MAD2-binding protein, CMT2, and its role in mitosis.". EMBO J. 21 (23): 6419–28. PMID 12456649. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Xia G, Luo X, Habu T, et al. (2005). "Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.". EMBO J. 23 (15): 3133–43. doi:10.1038/sj.emboj.7600322. PMID 15257285. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Yun MY, Kim SB, Park S, et al. (2007). "Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma.". Exp. Mol. Med. 39 (4): 508–13. PMID 17934339. 
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