User:MacGyverMagic/Discussions/Lipoproteins

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[edit] Wnt and (apo)lipoproteins

I'm trying to find info on the following questions in scientific articles, but the specific info I need is never mentioned in the articles I read. Can anyone recommend some specific articles?

  1. What kind of a lipid modification does the wnt protein have and what other proteins share this modification?
  2. Are HDL particles loaded on the plasma membrane or in the cell?
  3. What is the function of the apolipoproteins (especially Apolipoprotein E)?
  4. What proteins are involved in the binding, endocytosis and secretion of HDL, and what diseases are related to deficiencies those proteins?
  5. How does lipoprotein transport and recycling work in mammals?

Remember, although answers to these questions are appreciated, articles that may help to answer these questions are welcomed even more. -- [[User:MacGyverMagic|Mgm|(talk)]] 07:09, Oct 25, 2004 (UTC)

Have you tried PubMed or similar databases? --inks 07:14, 25 Oct 2004 (UTC)
I have. But they return such a huge amount of articles that I really have no clue what to read first. Tips on which key words to search for are appreciated as well.
Search terms "lipid modification the wnt protein" returned a single article (PMID 15189162), the abstract appears to be relevant to part 1 of your question. Also found this one (PMID 15181251) with "apoE function expression review". I find that a good way to do it is brute force your way through the PubMed results till you find a relevant paper, then go for the articles they reference. --inks 07:25, 25 Oct 2004 (UTC)
Thanks. I think I found the first one myself, I'll give the other one a read through. [[User:MacGyverMagic|Mgm|(talk)]] 07:55, Oct 25, 2004 (UTC)

For the more general answers on HDL metabolism I would recommend the latest edition of Scriver (Metabolic Basis of Inherited Disease) (2003 I think) which is available in all med school and many hospital libraries, often on the reference shelf. A medical librarian should immediately recognize the request as it is a multivolume "encyclopedic" reference work. This is a good place to start. If I have time later, I'll see what I can find in Medline on wnt. You can refine your search by restricting to "review" articles that mention wnt and lipoprotein. I'll bet that makes it a manageable number. If you are lucky, the text for one or more may be online.Alteripse 15:57, 25 Oct 2004 (UTC)

http://www.sigmaaldrich.com/Area_of_Interest/Biochemicals/Enzyme_Explorer/Key_Resources/Plasma__Blood_Protein/Apolipoprotein.html