Macrophage migration inhibitory factor

From Wikipedia, the free encyclopedia

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)

PDB rendering based on 1ca7.

Available structures: 1ca7, 1cgq, 1gcz, 1gd0, 1gif, 1ljt, 1mif, 1p1g, 2ooh, 2oow, 2ooz

Identifiers

Symbol(s)

MIF; GIF; GLIF; MMIF

External IDs

OMIM: 153620 MGI: 96982 HomoloGene: 55655

Gene ontology
Molecular Function:	• cytokine activity • protein binding • isomerase activity • phenylpyruvate tautomerase activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• prostaglandin biosynthetic process • inflammatory response • cell surface receptor linked signal transduction • cell proliferation • regulation of macrophage activation • negative regulation of apoptosis

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002415 (mRNA)
NP_002406 (protein)

NM_010798 (mRNA)
NP_034928 (protein)

Location

Chr 22: 22.37 - 22.57 Mb

n/a

Pubmed search

[1]

[2]

Macrophage migration inhibiting factor (MIF) is an inflammatory mediator associated with Rheumatoid Arthritis (RA) severity.

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.^[1]

[edit] References

^ Entrez Gene: MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor).

[edit] Further reading

Bucala R (1997). "MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response.". FASEB J. 10 (14): 1607–13. PMID 9002552.
Lolis E, Bucala R (2006). "Macrophage migration inhibitory factor.". Expert Opin. Ther. Targets 7 (2): 153–64. doi:10.1517/14728222.7.2.153. PMID 12667094.
Calandra T, Roger T (2003). "Macrophage migration inhibitory factor: a regulator of innate immunity.". Nat. Rev. Immunol. 3 (10): 791–800. doi:10.1038/nri1200. PMID 14502271.
Shimizu T (2005). "Role of macrophage migration inhibitory factor (MIF) in the skin.". J. Dermatol. Sci. 37 (2): 65–73. doi:10.1016/j.jdermsci.2004.08.007. PMID 15659324.
Larson DF, Horak K (2006). "Macrophage migration inhibitory factor: controller of systemic inflammation.". Critical care (London, England) 10 (2): 138. doi:10.1186/cc4899. PMID 16677407.