LZTS1

From Wikipedia, the free encyclopedia

Leucine zipper, putative tumor suppressor 1

Identifiers

LZTS1; FEZ1; F37

External IDs

OMIM: 606551 MGI: 2684762 HomoloGene: 10873

Gene ontology
Molecular Function:	• transcription factor activity
Cellular Component:	• nucleus • cytoplasm • membrane
Biological Process:	• transcription • regulation of transcription, DNA-dependent • cell cycle • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021020 (mRNA)
NP_066300 (protein)

NM_199364 (mRNA)
NP_955396 (protein)

Location

Chr 8: 20.15 - 20.21 Mb

Chr 8: 72.06 - 72.07 Mb

Pubmed search

[1]

[2]

Leucine zipper, putative tumor suppressor 1, also known as LZTS1, is a human gene.^[1]

[edit] References

^ Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1.

[edit] Further reading

Vecchione A, Baldassarre G, Ishii H, et al. (2007). "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.". Cancer Cell 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMID 17349584.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ono K, Uzawa K, Nakatsuru M, et al. (2004). "Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas.". Int. J. Oncol. 23 (2): 297–302. PMID 12851677.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hawkins GA, Mychaleckyj JC, Zheng SL, et al. (2002). "Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk.". Cancer Genet. Cytogenet. 137 (1): 1–7. PMID 12377406.
Ishii H, Vecchione A, Murakumo Y, et al. (2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. doi:10.1073/pnas.181222898. PMID 11504921.
Cabeza-Arvelaiz Y, Sepulveda JL, Lebovitz RM, et al. (2001). "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22.". Oncogene 20 (31): 4169–79. doi:10.1038/sj.onc.1204539. PMID 11464283.
Ishii H, Baffa R, Numata SI, et al. (1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3928–33. PMID 10097140.