LZTR1

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Leucine-zipper-like transcription regulator 1
Identifiers
Symbol(s) LZTR1; LZTR-1; MGC21205; TCFL2
External IDs OMIM: 600574 MGI: 1914113 HomoloGene: 4925
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8216 66863
Ensembl ENSG00000099949 ENSMUSG00000022761
Uniprot Q8N653 Q3V0X6
Refseq NM_006767 (mRNA)
NP_006758 (protein)		 NM_025808 (mRNA)
NP_080084 (protein)
Location Chr 22: 19.67 - 19.68 Mb Chr 16: 17.42 - 17.44 Mb
Pubmed search [1] [2]

Leucine-zipper-like transcription regulator 1, also known as LZTR1, is a human gene.[1]

This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome.[1]

[edit] References

  1. ^ a b Entrez Gene: LZTR1 leucine-zipper-like transcription regulator 1.

[edit] Further reading

  • Nacak TG, Leptien K, Fellner D, et al. (2006). "The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis.". J. Biol. Chem. 281 (8): 5065-71. doi:10.1074/jbc.M509073200. PMID 16356934. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Kurahashi H, Akagi K, Inazawa J, et al. (1995). "Isolation and characterization of a novel gene deleted in DiGeorge syndrome.". Hum. Mol. Genet. 4 (4): 541-9. PMID 7633402. 
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