LYVE1

From Wikipedia, the free encyclopedia

Extracellular link domain containing 1

Identifiers

XLKD1; CRSBP-1; HAR; LYVE-1

External IDs

OMIM: 605702 MGI: 2136348 HomoloGene: 4868

Gene ontology
Molecular Function:	• transmembrane receptor activity • hyaluronic acid binding
Cellular Component:	• membrane fraction • plasma membrane • integral to plasma membrane
Biological Process:	• glycosaminoglycan catabolic process • transport • cell motility • cell adhesion • cell-matrix adhesion • response to wounding • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006691 (mRNA)
NP_006682 (protein)

NM_053247 (mRNA)
NP_444477 (protein)

Location

Chr 11: 10.54 - 10.55 Mb

Chr 7: 110.64 - 110.65 Mb

Pubmed search

[1]

[2]

Extracellular link domain containing 1, also known as XLKD1, is a human gene.^[1]

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.^[1] LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes. So far the physiological role for this receptor is till the subject of debate, but evolutionary conservation suggests an important role.

[edit] References

^ ^a ^b Entrez Gene: XLKD1 extracellular link domain containing 1.

[edit] Further reading

Jackson DG (2003). "The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1.". Trends Cardiovasc. Med. 13 (1): 1-7. PMID 12554094.
Banerji S, Ni J, Wang SX, et al. (1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan.". J. Cell Biol. 144 (4): 789-801. PMID 10037799.
Cunnick GH, Jiang WG, Gomez KF, Mansel RE (2001). "Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model.". Biochem. Biophys. Res. Commun. 288 (4): 1043-6. doi:10.1006/bbrc.2001.5869. PMID 11689016.
Mouta Carreira C, Nasser SM, di Tomaso E, et al. (2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.". Cancer Res. 61 (22): 8079-84. PMID 11719431.
Cursiefen C, Schlötzer-Schrehardt U, Küchle M, et al. (2002). "Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin.". Invest. Ophthalmol. Vis. Sci. 43 (7): 2127-35. PMID 12091407.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Huang SS, Tang FM, Huang YH, et al. (2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1.". J. Biol. Chem. 278 (44): 43855-69. doi:10.1074/jbc.M306411200. PMID 12912978.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Nguyen VA, Kutzner H, Fürhapter C, et al. (2006). "Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence.". Mod. Pathol. 19 (2): 291-8. doi:10.1038/modpathol.3800537. PMID 16424896.
Gu B, Alexander JS, Gu Y, et al. (2007). "Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta.". Lymphatic research and biology 4 (1): 11-7. doi:10.1089/lrb.2006.4.11. PMID 16569201.
Llovet JM, Chen Y, Wurmbach E, et al. (2007). "A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis.". Gastroenterology 131 (6): 1758-67. doi:10.1053/j.gastro.2006.09.014. PMID 17087938.