Lysine dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a lysine dehydrogenase (EC 1.4.1.15) is an enzyme that catalyzes the chemical reaction

L-lysine + NAD⁺ 1,2-didehydropiperidine-2-carboxylate + NH₃ + NADH + H⁺

Thus, the two substrates of this enzyme are L-lysine and NAD⁺, whereas its 4 products are 1,2-didehydropiperidine-2-carboxylate, NH₃, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-lysine:NAD+ oxidoreductase (deaminating, cyclizing).

[edit] References

• IUBMB entry for 1.4.1.15
• BRENDA references for 1.4.1.15 (Recommended.)
• PubMed references for 1.4.1.15
• PubMed Central references for 1.4.1.15
• Google Scholar references for 1.4.1.15
• Burgi W, Richterich R, Colombo JP (1966). "L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance". Nature. 211: 854–5. doi:10.1038/211854a0. PMID 4291003. 

[edit] External links

The CAS registry number for this enzyme class is 68073-29-0.

• IUBMB entry for 1.4.1.15

• KEGG entry for 1.4.1.15

• BRENDA entry for 1.4.1.15

• NiceZyme view of 1.4.1.15

• EC2PDB: PDB structures for 1.4.1.15

• PRIAM entry for 1.4.1.15

• PUMA2 entry for 1.4.1.15

• IntEnz: Integrated Enzyme entry for 1.4.1.15

• MetaCyc entry for 1.4.1.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050069: lysine dehydrogenase

• AMIGO entry for GO code 0050069: lysine dehydrogenase