Lysine-tRNAPyl ligase

From Wikipedia, the free encyclopedia

In enzymology, a lysine-tRNAPyl ligase (EC 6.1.1.25) is an enzyme that catalyzes the chemical reaction

ATP + L-lysine + tRNAPyl AMP + diphosphate + L-lysyl-tRNAPyl

The 3 substrates of this enzyme are ATP, L-lysine, and tRNA(Pyl), whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA(Pyl).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-lysine:tRNAPyl ligase (AMP-forming).

[edit] References

• IUBMB entry for 6.1.1.25
• BRENDA references for 6.1.1.25 (Recommended.)
• PubMed references for 6.1.1.25
• PubMed Central references for 6.1.1.25
• Google Scholar references for 6.1.1.25
• Srinivasan G, James CM, Krzycki JA (2002). "Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA". Science. 296: 1459–62. doi:10.1126/science.1069588. PMID 12029131. 
• Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK (2002). "A new UAG-encoded residue in the structure of a methanogen methyltransferase". Science. 296: 1462–6. doi:10.1126/science.1069556. PMID 12029132. 

[edit] External links

The CAS registry number for this enzyme class is 782472-12-2.

• IUBMB entry for 6.1.1.25

• KEGG entry for 6.1.1.25

• BRENDA entry for 6.1.1.25

• NiceZyme view of 6.1.1.25

• EC2PDB: PDB structures for 6.1.1.25

• PRIAM entry for 6.1.1.25

• PUMA2 entry for 6.1.1.25

• IntEnz: Integrated Enzyme entry for 6.1.1.25

• MetaCyc entry for 6.1.1.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050562: lysine-tRNA(Pyl) ligase

• AMIGO entry for GO code 0050562: lysine-tRNA(Pyl) ligase