LYK5

From Wikipedia, the free encyclopedia

Protein kinase LYK5

Identifiers

LYK5; FLJ90524; STRAD

External IDs

OMIM: 608626 MGI: 1919399 HomoloGene: 12448

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein amino acid phosphorylation • protein export from nucleus • cell cycle • activation of protein kinase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001003786 (mRNA)
NP_001003786 (protein)

NM_028126 (mRNA)
NP_082402 (protein)

Location

Chr 17: 59.13 - 59.17 Mb

n/a

Pubmed search

[1]

[2]

Protein kinase LYK5, also known as LYK5, is a human gene.^[1]

[edit] References

^ Entrez Gene: LYK5 protein kinase LYK5.

[edit] Further reading

Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity.". Trends Cell Biol. 14 (6): 312-9. doi:10.1016/j.tcb.2004.04.001. PMID 15183188.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. PMID 12747765.
Baas AF, Boudeau J, Sapkota GP, et al. (2003). "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.". EMBO J. 22 (12): 3062-72. doi:10.1093/emboj/cdg292. PMID 12805220.
Boudeau J, Baas AF, Deak M, et al. (2003). "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.". EMBO J. 22 (19): 5102-14. doi:10.1093/emboj/cdg490. PMID 14517248.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Milburn CC, Boudeau J, Deak M, et al. (2004). "Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.". Nat. Struct. Mol. Biol. 11 (2): 193-200. doi:10.1038/nsmb716. PMID 14730349.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833-43. doi:10.1038/sj.emboj.7600110. PMID 14976552.
Boudeau J, Scott JW, Resta N, et al. (2005). "Analysis of the LKB1-STRAD-MO25 complex.". J. Cell. Sci. 117 (Pt 26): 6365-75. doi:10.1242/jcs.01571. PMID 15561763.