Luis Agote

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Luis Agote

Luis Agote (September 22, 1868–November 12, 1954) was an Argentinian physician and researcher. He was one of the first to perform a non-direct blood transfusion using sodium citrate as an anticoagulant. While Agote was the first to perform this procedure in Latin America, the Belgian doctor Albert Hustin was the first to perform it world-wide. The procedure took place in Rawson hospital in the city of Buenos Aires on November 9, 1914.

[edit] Biography

He studied first in the Colegio Nacional de Buenos Aires, and then at the University of Buenos Aires, where he was also a teacher. He graduated as a doctor in 1893 with a thesis about hepatitis supurada. He became Secretary of the National Department of Hygiene in 1894 and became head of the leper hospital in 1895 on the island of Martin Garcia. He was elected Deputy in 1910 and Senator in 1916 of the legislature in Argentina.

[edit] First Recorded Transfusions

The first recorded blood transfusion was made between dogs by the English doctor Richard Lower around 1666. In 1667, the French scientist Juan Bautista Denys made a transfusion to a human using animal blood. In 1900, Karl Landsteiner identified some of the blood substances responsible for the agglutination of red blood cells, identifying blood groups for the first time and some of their incompatibilities.

Direct transfusions were still not practiced at the beginning of the 20th century because it was impossible to keep unaltered blood outside the body for later use. After 6-12 minutes, coagulation begins manifested initially by a gradual increase of viscosity that terminates with almost complete solidification. Coagulation is the defense of an organism to staunch wounds and minimize hemorrhages. Now we know that clotting is almost totally formed by red blood cells fastened by a network of filaments of fibrin.

Fibrin do not normally exist in blood and are created starting from protein plasma by the action of the thrombin enzyme. Similarly, thrombin are not naturally present in blood and are created by the precursor substance prothombrin, in a process that involves platelets, some exiting from calcium and substances produced by lesioned materials. Since clots are not created if there is a lack of some of these elements, the addition of sodium citrate (which eliminates calcium ions from blood) prevents its formation.