LTK (gene)

From Wikipedia, the free encyclopedia

Leukocyte tyrosine kinase

Identifiers

LTK; TYK1

External IDs

OMIM: 151520 MGI: 96840 HomoloGene: 37613

Gene ontology
Molecular Function:	• nucleotide binding • transmembrane receptor protein tyrosine kinase activity • receptor activity • ATP binding • transferase activity
Cellular Component:	• soluble fraction • plasma membrane • integral to plasma membrane
Biological Process:	• protein amino acid phosphorylation • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002344 (mRNA)
NP_002335 (protein)

NM_008523 (mRNA)
NP_032549 (protein)

Location

Chr 15: 39.58 - 39.59 Mb

Chr 2: 119.31 - 119.45 Mb

Pubmed search

[1]

[2]

Leukocyte tyrosine kinase, also known as LTK, is a human gene.^[1]

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: LTK leukocyte tyrosine kinase.

[edit] Further reading

Krolewski JJ, Dalla-Favera R (1991). "The ltk gene encodes a novel receptor-type protein tyrosine kinase.". EMBO J. 10 (10): 2911–9. PMID 1655406.
Krolewski JJ, Lee R, Eddy R, et al. (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes.". Oncogene 5 (3): 277–82. PMID 2156206.
Maru Y, Hirai H, Takaku F (1990). "Human ltk: gene structure and preferential expression in human leukemic cells.". Oncogene Res. 5 (3): 199–204. PMID 2320375.
Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.". Nature 333 (6174): 672–6. doi:10.1038/333672a0. PMID 2836739.
Toyoshima H, Kozutsumi H, Maru Y, et al. (1993). "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. PMID 7685902.
Richard I, Broux O, Chiannilkulchai N, et al. (1995). "Regional localization of human chromosome 15 loci.". Genomics 23 (3): 619–27. PMID 7851890.
Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.". Oncogene 9 (10): 2991–8. PMID 8084603.
Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines.". Biochem. Biophys. Res. Commun. 190 (2): 674–9. doi:10.1006/bbrc.1993.1101. PMID 8427607.
Ueno H, Sasaki K, Kozutsumi H, et al. (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.". J. Biol. Chem. 271 (44): 27707–14. PMID 8910363.
Snijders AJ, Ho SC, Haase VH, et al. (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin.". J. Biol. Chem. 272 (2): 1297–301. PMID 8995435.
Ueno H, Honda H, Nakamoto T, et al. (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.". Oncogene 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.
Espanel X, Huguenin-Reggiani M, Van Huijsduijnen RH (2003). "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.". Protein Sci. 11 (10): 2326–34. PMID 12237455.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Li N, Nakamura K, Jiang Y, et al. (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.". Hum. Mol. Genet. 13 (2): 171–9. doi:10.1093/hmg/ddh020. PMID 14695357.