LSM4

From Wikipedia, the free encyclopedia

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Identifiers

LSM4; YER112W

External IDs

OMIM: 607284 MGI: 1354692 HomoloGene: 5837

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus • snRNP U6
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012321 (mRNA)
NP_036453 (protein)

NM_015816 (mRNA)
NP_056631 (protein)

Location

Chr 19: 18.28 - 18.29 Mb

Chr 8: 73.61 - 73.61 Mb

Pubmed search

[1]

[2]

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae), also known as LSM4, is a human gene.^[1]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae).

[edit] Further reading

Singer J, Roberts-Ems J, Luthardt FW, Riggs AD (1980). "Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit.". Nucleic Acids Res. 7 (8): 2369-85. PMID 523320.
Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.". EMBO J. 18 (12): 3451-62. doi:10.1093/emboj/18.12.3451. PMID 10369684.
Achsel T, Brahms H, Kastner B, et al. (1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.". EMBO J. 18 (20): 5789-802. doi:10.1093/emboj/18.20.5789. PMID 10523320.
Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).". J. Biol. Chem. 275 (34): 26370-5. doi:10.1074/jbc.M003299200. PMID 10851237.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera.". Arthritis Rheum. 46 (3): 726-34. doi:10.1002/art.10220. PMID 11920408.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.". RNA 8 (12): 1489-501. PMID 12515382.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Fürst J, Schedlbauer A, Gandini R, et al. (2005). "ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.". J. Biol. Chem. 280 (35): 31276-82. doi:10.1074/jbc.M500541200. PMID 15905169.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Yang ZQ, Streicher KL, Ray ME, et al. (2007). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.". Cancer Res. 66 (24): 11632-43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.